Discovery of new fenamate-based derivatives as anticancer agents and potent VEGFR-2 inhibitors

VEGFR-2 is a critical target for the treatment of solid tumors. This work represents synthetic approaches to new class fenamate-based derivatives with essential pharmacophoric properties comparable inhibitors. The reaction tolfenamic acid hydrazide substituted phenacyl bromide, and phenylisothiocynate produced novel (TA) (compounds 4 5). molecules were validated using spectroscopic techniques such as FT-IR 1HNMR. Docking tests performed determine how synthesized chemicals bind putative molecular target, VEGFR-2. docking results demonstrated that compounds could correctly. Finally, computational physicochemical analysis most active candidates revealed they have favorable assets reasonable drug-likeness reports.